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Vol. 25  ·  Ketamine  ·  July 2026
KETAMINE
Norketamine, the therapy-vs-illicit context, and a short parent half-life

Ketamine is an NMDA-antagonist dissociative anesthetic and analgesic, increasingly used therapeutically at subanesthetic doses for neuropathic pain and treatment-resistant depression, and also used illicitly for its dissociative effects. LC-MS/MS measures ketamine and its active metabolite norketamine, which often exceeds the parent and extends the detection window.1

Why This Matters Now

Renewed clinical use of ketamine for depression and pain means a positive result increasingly reflects legitimate therapy, not only illicit use, so interpretation requires the clinical context. Illicit use persists, primarily among young adults, for its hallucinogenic effects.2

⚠ A ketamine positive does not distinguish medical from illicit use. Interpret against the treatment history; testing may also confirm elimination before starting a new therapy.
Clinical Presentation
INTOXICATION
Dissociation, analgesia
Hallucinations, vivid dreams
Delirium, confusion
Nystagmus
Tachycardia, hypertension
WITHDRAWAL
No classic physical withdrawal
Psychological craving with heavy use
Low mood, anxiety
Insomnia
Chronic use: urinary tract toxicity
Important: Chronic heavy ketamine use is associated with ulcerative cystitis and urinary tract damage. Emergence reactions (hallucinations, delirium) are common; supportive care and a low-stimulation environment help.
UDT Considerations

Ketamine is not on standard immunoassay panels; targeted LC-MS/MS measures ketamine and norketamine. Because norketamine often exceeds ketamine and persists longer, measuring both improves detection.3 Ordering may confirm ketamine presence, verify complete elimination before a new therapy, or check for illicit use.1

Clinical Guidance
  • Order targeted LC-MS/MS for ketamine and norketamine; routine screens do not detect it.1
  • Interpret a positive with the treatment history; medical and illicit use are not distinguishable by the assay.
  • Use norketamine to extend the detection window and confirm exposure.3
  • Screen for urinary tract symptoms in chronic heavy users.
  • Correlate levels with timing; the parent half-life is short (2 to 3 hours).
Point-of-Care Testing Availability
Available strips
No routine immunoassay reliably detects ketamine.
Clinical use
Detection requires targeted LC-MS/MS for ketamine and norketamine.
Limitations
Norketamine often exceeds ketamine and extends the window.
KETAMINE  |  Clinical & Program Guidance
Tox In Focus Vol. 25  ·  July 2026  ·  Page 2 of 2
Interpreting the Test Result
▲  If Testing Is Positive

Confirms recent exposure. Ketamine and/or norketamine indicates use within roughly 2 to 3 days.

Does not distinguish source. Medical and illicit ketamine are not differentiated by the assay.

Norketamine extends the window. The metabolite often exceeds the parent and persists longer.3

Metabolism & Urinary Markers

Ketamine analytes measured on definitive testing.

MetaboliteClinical Significance
Ketamine (parent)Short half-life (~2 to 3 h); NMDA antagonist.
NorketamineActive metabolite; often exceeds parent and extends the window.
Key References
  1. Blonk MI, et al. Use of oral ketamine in chronic pain management. Eur J Pain. 2010;14(5):466-472.
  2. US Drug Enforcement Administration. Ketamine. Drugs and Chemicals of Concern.
  3. Moore KA, et al. Urine concentrations of ketamine and norketamine following illegal consumption. J Anal Toxicol. 2001;25:583-588.
DISCLAIMER: This document is intended for clinical reference and educational purposes only. It does not constitute medical, legal, or professional advice and should not replace independent clinical or programmatic judgment. Content reflects published data available at time of preparation. ToxiPharm LLC makes no warranties regarding completeness or applicability in all settings.  |   © 2026 ToxiPharm LLC  |  toxipharm.org
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